Atherosclerosis in diabetes mellitus: role of inflammation.
Indian J Med Sci
;
2007 May; 61(5): 292-306
Artigo
em Inglês
| IMSEAR
| ID: sea-66906
ABSTRACT
Inflammation plays a central role in the pathophysiology of atherosclerosis, starting from initiation, through progression and ultimately the thrombotic complications of atherosclerosis. Diabetes mellitus is a major risk factor for atherosclerosis. Hyperglycemia-induced endothelial dysfunctions, along with hypercoagulable potential of diabetes mellitus, accelerate the process of atherothrombotic complications. Therefore, clinically feasible markers to monitor subtle systemic inflammatory burden and specific add-on therapy for the same constitute need of the present day. The understanding of the concept of inflammation in diabetes-accelerated atherosclerosis can be used practically to predict future cardiovascular risk by evaluating inflammatory biomarkers and to design clinical trials making inflammation as a therapeutic target.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Endotélio Vascular
/
Biomarcadores
/
Fatores de Risco
/
Estresse Oxidativo
/
Progressão da Doença
/
Complicações do Diabetes
/
Aterosclerose
/
Inflamação
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Med Sci
Ano de publicação:
2007
Tipo de documento:
Artigo
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