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Bioequivalence studies of celiprolol in healthy human volunteers.
Indian J Med Sci ; 1996 Jul; 50(7): 234-8
Artigo em Inglês | IMSEAR | ID: sea-67804
ABSTRACT
Thus bioequivalence between the two products was established by undertaking this study. From table 1 it can be seen that the standard deviation at the various sampling points is high indicating varying absorption rates in individual volunteers, but this was observed in case of both the products. Also, since the study design was complete crossover, this high standard deviation was not due to any study design variable. As celiprolol shows non-linear1 dose related absorption kinetics this high value of standard deviation may be due to the intersubject variation during the absorption process. However all the pharmacokinetic parameters showed a comparable profile when statistically evaluated for any significant difference between the two products.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Humanos / Masculino / Equivalência Terapêutica / Método Duplo-Cego / Celiprolol / Antagonistas Adrenérgicos beta / Estudos Cross-Over / Adulto Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: Indian J Med Sci Ano de publicação: 1996 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Humanos / Masculino / Equivalência Terapêutica / Método Duplo-Cego / Celiprolol / Antagonistas Adrenérgicos beta / Estudos Cross-Over / Adulto Tipo de estudo: Ensaio Clínico Controlado Idioma: Inglês Revista: Indian J Med Sci Ano de publicação: 1996 Tipo de documento: Artigo