Evaluation of the efficacy of mifepristone/misoprostol and methotrexate/misoprostol for medical abortion.
Indian J Med Sci
;
2005 Jul; 59(7): 301-6
Artigo
em Inglês
| IMSEAR
| ID: sea-68111
ABSTRACT
BACKGROUND:
Unsafe abortion is a major cause of mortality among women in India accounting for 12% of all maternal deaths. In developing countries, annually, up to 200,000 women die of complications after illegal abortion. Medical abortion is potentially a simple and a safe method for use in developing countries. We conducted a prospective controlled trial to compare the efficacy of low-lose mifepristone and methotrexate for medical abortion.OBJECTIVE:
To find out the efficacy of low-dose mifepristone and methotrexate for inducing abortion.METHOD:
In this prospective clinical study, 100 women opted for a medical method of abortion. Out of these, 50 patients were given 50 mg/m2 of methotrexate intramuscularly followed by 800 micro gm of intravaginal misoprostol, and 50 patients were given 200 mg of mifepristone orally followed by 800 micro gm of intravaginal misoprostol. MAIN OUTCOMEMEASURES:
Complete abortion was the principal outcome measure. Secondary outcome measures were side effects and acceptability data.RESULTS:
The rate of expulsion by first week after initiation of treatment was 58% in methotrexate and 98% in mifepristone group (P <0.001).CONCLUSION:
Low-dose mifepristone and intravaginal misoprostol is safe, effective, and well tolerated as compared to methotrexate and misoprostol.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Abortivos
/
Gravidez
/
Distribuição de Qui-Quadrado
/
Mifepristona
/
Metotrexato
/
Estudos Prospectivos
/
Resultado do Tratamento
/
Misoprostol
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudos de avaliação
/
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Med Sci
Ano de publicação:
2005
Tipo de documento:
Artigo
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