Anti-inflammatory and analgesic effect of herbal preparation: septilin.
Indian J Med Sci
;
2001 Apr; 55(4): 195-202
Artigo
em Inglês
| IMSEAR
| ID: sea-68239
ABSTRACT
Septilin a proprietary herbal preparation has been reported to have wound healing and immunomodulatory properties. The present study was, therefore, designed to ascertain the anti-inflammatory and analgesic properties of septilin in rats and mice by oral route. Anti-inflammatory activity was assessed by using acute (carrageenan-induced paw oedema), sub-acute (cotton pellet granuloma) and chronic (Freund's adjuvant induced-arthritis) models of inflammation. Administration of septilin in a dose of 500 mg/kg orally produced significant anti-inflammatory effect in all experimental models of inflammation. However, the anti-inflammatory effect was more in chronic model when compared to reference standard drug (Prednisolone). Septilin (500 mg/kg) produced significant analgesic effect on tall flick test. However, the effect was less when compared to morphine (5 mg/kg) but when septilin was combined with subanalgesic dose of morphine (2.5 mg/kg) the analgesic effect was more than the either drug given alone. On GAA induced writhing test septilin produced significant analgesic effect at a dose of 750 mg/kg which was comparable to diclofenac (50 mg/kg). However, subanalgesic dose of septilin (500 mg/kg) when combined with diclofenac (25 mg/kg), analgesic effect was enhanced significantly.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Medição da Dor
/
Masculino
/
Extratos Vegetais
/
Anti-Inflamatórios não Esteroides
/
Modelos Animais
/
Analgésicos
/
Inflamação
/
Animais
/
Fitoterapia
Idioma:
Inglês
Revista:
Indian J Med Sci
Ano de publicação:
2001
Tipo de documento:
Artigo
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