Effects of flunarizine on dopamine dependent behaviours in rats.
Indian J Med Sci
;
1999 Feb; 53(2): 43-8
Artigo
em Inglês
| IMSEAR
| ID: sea-68938
ABSTRACT
1. Radio-ligand binding study has demonstrated that flunarizine has a high affinity for the rat striatal D 2 dopamine (DA) receptors. 2. In the present behavioural study conducted in rats it was observed that flunarizine, unlike the postsynaptic striatal D 2 DA receptor agonist apomorphine, did not induce stereotyped behaviour (SB) in rats. This indicates that flunarizine does not act as an agonist at the postsynaptic striatal D 2 DA receptors. 3. Flunarizine however, like the postsynaptic striatal D 2 DA receptor antagonist haloperiodal, inhibited the conditioned avoidance response, induced catalepsy and antagonized the SB induced by the DA agonists apomorphine and methamphetamine. 4. Our findings indicate that flunarizine acts as a postsynaptic striatal D 2 DA receptor antagonist.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ratos
/
Comportamento Estereotipado
/
Aprendizagem da Esquiva
/
Comportamento Animal
/
Masculino
/
Bloqueadores dos Canais de Cálcio
/
Flunarizina
/
Apomorfina
/
Dopamina
/
Catalepsia
Idioma:
Inglês
Revista:
Indian J Med Sci
Ano de publicação:
1999
Tipo de documento:
Artigo
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