Anticonvulsant hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro.
Indian J Med Sci
;
2006 Feb; 60(2): 59-63
Artigo
em Inglês
| IMSEAR
| ID: sea-69071
ABSTRACT
Anticonvulsant hypersensitivity syndrome (AHS) developing to lamotrigine, a non-aromatic anticonvulsant, has rarely been reported. We present a two-year-old boy with refractory epilepsy on valproic acid and lamotrigine therapy who developed fever and a maculopapular itchy rash. Blood investigations detected lymphocytosis and thrombocytopenia. With a presumptive diagnosis of AHS, lamotrigine was discontinued. The fever and rash resolved over the next three days and the child was discharged on valproic acid and clobazam. The diagnosis was confirmed by in vitro lymphocyte toxicity assay, which not only demonstrated increased cell death following exposure to lamotrigine, but also to the three first-line aromatic anticonvulsants phenytoin, phenobarbital and carbamazepine. The potential of first-line aromatic anticonvulsants to cause AHS should be remembered in a patient who has developed AHS on exposure to lamotrigine. Timely recognition of this rare but potentially fatal drug reaction is important.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Síndrome
/
Trombocitopenia
/
Triazinas
/
Humanos
/
Masculino
/
Linfócitos
/
Pré-Escolar
/
Hipersensibilidade a Drogas
/
Epilepsia
/
Linfocitose
Idioma:
Inglês
Revista:
Indian J Med Sci
Ano de publicação:
2006
Tipo de documento:
Artigo
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