G6PD deficiency in Vataliya Prajapati community settled in Surat.
Indian J Med Sci
;
2005 Feb; 59(2): 51-6
Artigo
em Inglês
| IMSEAR
| ID: sea-69364
ABSTRACT
BACKGROUND:
A Study on Vataliya Prajapati was published earlier but heterozygous females were not identified.AIMS:
To compare incidence of glucose-6-phosphate dehydrogenase (G6PD) deficiency in random and unrelated subjects, present and previous study and as per their original habitat. Incidence of heterozygous deficiency and clinical implication of deficiency was also determined. SETTINGS ANDDESIGN:
Camps were organized in Katargaon and Amroli regions. Blood specimens, with relevant demographic information, were collected from those who attended the camp. METHODS ANDMATERIAL:
A total of 1644 random blood samples were collected from 404 families participating in the camps. Nitroblue tetrazolium dye test was used for G6PD deficiency screening and quantitative assay for measurement of G6PD enzyme activity. STATISTICAL ANALYSIS USED Chi2 test was used to evaluate significance and mean values were compared by the Student's ''t'' test.RESULTS:
Incidence of G6PD deficiency was found as 22% among all the random samples tested. However, the G6PD deficiency among unrelated members was 27.9% in males and 12.4% (P< 0.001,df 1). The 13.9% of the females with heterozygous G6PD deficient status, together with the homozygous deficient phenotype makes the incidence comparable with males. Incidence of deficiency was comparable with previous study, in Katargam and Amroli and in Amerli and Bhavganar districts. Deficient subjects had mild anemia and hemolytic crisis rarely occurred.CONCLUSION:
Vataliya Prajapatis have high incidence of G6PD deficiency without severe chronic hemolytic anemia. However before prescribing medicines physician should know the G6PD status of a Vataliya Prajapati patient.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fenótipo
/
Feminino
/
Humanos
/
Masculino
/
Programas de Rastreamento
/
Doença Crônica
/
Incidência
/
Deficiência de Glucosefosfato Desidrogenase
/
Heterozigoto
/
Índia
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
/
Estudo de rastreamento
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Med Sci
Ano de publicação:
2005
Tipo de documento:
Artigo
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