Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease.
Indian J Ophthalmol
;
2000 Dec; 48(4): 307-9
Artigo
em Inglês
| IMSEAR
| ID: sea-70505
ABSTRACT
BACKGROUND:
Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease.METHODS:
TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17).RESULTS:
Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01).CONCLUSION:
The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Doenças Retinianas
/
Vasculite
/
Plaquetas
/
Humanos
/
Biomarcadores
/
Peroxidação de Lipídeos
/
Neovascularização Retiniana
/
Adolescente
/
Substâncias Reativas com Ácido Tiobarbitúrico
/
Progressão da Doença
Idioma:
Inglês
Revista:
Indian J Ophthalmol
Ano de publicação:
2000
Tipo de documento:
Artigo
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