Langerhans cell histiocytosis in children less than 2 years of age.
Indian Pediatr
;
1999 Jan; 36(1): 29-36
Artigo
em Inglês
| IMSEAR
| ID: sea-7052
ABSTRACT
OBJECTIVE:
To study the clinical profile and outcome of langerhans cell histiocytosis in children upto 2 years of life.DESIGN:
Retrospective analysis.METHODS:
Medical records of Children upto 2 years of age with a diagnosis of langerhans cell histiocytosis (LCH) were analyzed. Their clinical pattern, treatment modalities and outcome were studied. The patients Were categorized into 2 groups according to their clinical presentation (i) Subject without organ dysfunction; and (ii) cases with organ dysfunction. Treatment considered of surgical intervention, radiotherapy, chemotherapy or combination of all these modalities depending upto the extent of disease.RESULTS:
There were 20 children upto 2 years of age with histiocytosis during the 12 year period (January 1983 - December 1994). The median age at diagnosis was 18 months (range 52 days - 24 months). Of the twenty patients,13 patients didn't have organ dysfunction and 7 had organ dysfunction. Out of the 13 children without organ dysfunction eleven patients received treatment and all of them are alive free of disease with a median follow up of 62 months. But all children with organ dysfunction succumbed to disease within a few weeks.CONCLUSION:
Children under 2 years of age with localised and or multifocal LCH without organ dysfunction have a good prognosis and they should not be exposed to aggressive form of treatment. All children with organ dysfunction require multi-agent chemotherapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Recidiva
/
Vimblastina
/
Doenças da Medula Óssea
/
Indução de Remissão
/
Feminino
/
Humanos
/
Masculino
/
Prednisolona
/
Pré-Escolar
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
1999
Tipo de documento:
Artigo
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