Comparison of clinical and microbiological profiles in smear-positive and smear-negative cases of suspected microbial keratitis.
Indian J Ophthalmol
;
2007 Jan-Feb; 55(1): 21-5
Artigo
em Inglês
| IMSEAR
| ID: sea-71441
ABSTRACT
PURPOSE:
To examine the hypothesis that initial smear examination results have a significant bearing on the management and outcome of suspected microbial keratitis. MATERIALS ANDMETHODS:
One hundred and seventy consecutive patients with suspected microbial keratitis were included in a prospective nonrandomized comparative study and their detailed clinical and microbiological data (smears and cultures of corneal scrapings) were captured on a predesigned corneal ulcer database. Patients were divided into two groups Group 1 included 68 patients with corneal scrapings negative in smears while Group 2 included 102 patients with corneal scrapings positive in smears. The two groups were compared for their clinico-microbiological profile, management and clinical outcome. The outcome was noted at three months. Fisher's exact test was applied for statistical analysis.RESULTS:
Cultures were sterile in 57.3% of patients in Group 1 compared to 17.6% in Group 2. Scrapings that grew S. pneumoniae, gram-negative organisms, fungi and Acanthamoeba were more often positive in smears (18.6%, 11.8%, 19.6% and 2.9% respectively). While data on duration of prior treatment was not available, prior medication made no significant difference to smear results. More (79.3%) patients of Group 1 had small infiltrate size (CONCLUSIONS:
Initial smear examination helps in instituting specific therapy thereby improving the outcome in cases of microbial keratitis. Positive smears indicate greater severity of disease and prior medication may not be a significant cause of smear negativity.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Infecções Bacterianas
/
Humanos
/
Ceratite por Acanthamoeba
/
Estudos Prospectivos
/
Técnicas Microbiológicas
/
Córnea
/
Ceratite
/
Antibacterianos
/
Micoses
/
Antifúngicos
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Ophthalmol
Ano de publicação:
2007
Tipo de documento:
Artigo
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