Successful treatment of rotavirus-induced diarrhoea in suckling mice with egg yolk immunoglobulin.
J Health Popul Nutr
;
2007 Dec; 25(4): 465-8
Artigo
em Inglês
| IMSEAR
| ID: sea-719
ABSTRACT
The role of specific immunoglobulins at mucosal sites in imparting protection against disease, such as rotavirus-associated diarrhoea, is well-established. Oral immunoglobulin therapy with egg yolk-derived anti-rotavirus immunoglobulins has previously been shown to achieve moderate therapeutic effect in diarrhoea due to rotavirus in a clinical trial. Here, data on the therapeutic potential of the same immunoglobulin preparation in an infant mouse model of rotavirus-induced diarrhoea is presented. The use of an animal model has allowed therapy to be evaluated with higher doses of immunoglobulins and has suggested that an improved therapeutic effect can be achieved by increasing the dose in the clinical setting.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Infecções por Rotavirus
/
Humanos
/
Imunoglobulinas
/
Distribuição Aleatória
/
Imunização Passiva
/
Rotavirus
/
Diarreia
/
Modelos Animais de Doenças
/
Gema de Ovo
/
Animais
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Revista:
J Health Popul Nutr
Assunto da revista:
Gastroenterology
/
Nutritional Sciences
/
Public Health
Ano de publicação:
2007
Tipo de documento:
Artigo
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