Thyroid dysfunction in multi-transfused iron loaded thalassemia patients.
Indian Pediatr
;
1992 Aug; 29(8): 997-102
Artigo
em Inglês
| IMSEAR
| ID: sea-7238
ABSTRACT
Seventy-two transfusion-dependent iron loaded thalassemia patients were investigated for thyroid dysfunction by estimating circulating thyroid hormones (T4 and T3) and basal thyroid stimulating hormone (TSH). They were also evaluated for their liver function (biochemically) and iron overload by estimating serum ferritin. Thyroid failure (hypothyroidism) was documented in 14 patients (19.4%). In all, 3 groups were seen, i.e. Group 1 Normal T4, T3, TSH (58 patients 80.6%); Group 2 Compensated hypothyroidism characterized by normal T4, T3 and raised TSH (9 patients 12.5%); Group 3 Decompensated hypothyroidism characterized by decreased T4 and increased TSH (5 patients 6.9%). Interestingly, impaired thyroid function could not be correlated with age, amount of blood transfused, liver dysfunction or degree of iron overload. It is postulated that an inter-play between chronic hypoxia, liver dysfunction and iron overload may be responsible for the thyroid damage.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Testes de Função Tireóidea
/
Hormônios Tireóideos
/
Estatura
/
Feminino
/
Humanos
/
Masculino
/
Terapia por Quelação
/
Criança
/
Pré-Escolar
/
Talassemia beta
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
1992
Tipo de documento:
Artigo
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