Effect of levamisole as an immunomodulating agent in trophoblastic lesions.
Indian J Pathol Microbiol
;
1993 Jan; 36(1): 32-7
Artigo
em Inglês
| IMSEAR
| ID: sea-72746
ABSTRACT
Both cell mediated immunity and humoral immunity was assessed in 16 patients of hydatidiform mole and 6 patients of choriocarcinoma. Fifty percent patients of choriocarcinoma and 11 patients of vesicular mole were given levamisole (LVM) trial and were followed for 2 months. Absolute lymphocyte count (ALC) was significantly increased in vesicular mole after levamisole treatment but in choriocarcinoma no effect was obtained. Marked improvement of T cell rosette count was also seen in LVM treated patient of both vesicular mole (p < 0.001) and choriocarcinoma. Cutaneous DTH response to 24 DNCB in vesicular mole was also increased after LVM. Before treatment only 31.25% patients had strong cutaneous response but after treatment 53.35% patients had strong response, while cases of choriocarcinoma were unaffected. LVM also raised all the serum immunoglobulins (IgG, IgM, IgA) in both vesicular mole and choriocarcinoma. Hence, levamisole therapy was found to have a beneficial effect on both cellular and humoral immunity in the lesions of trophoblasts.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Formação de Roseta
/
Neoplasias Uterinas
/
Feminino
/
Humanos
/
Imunoglobulinas
/
Gravidez
/
Coriocarcinoma
/
Mola Hidatiforme
/
Adjuvantes Imunológicos
/
Levamisol
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
1993
Tipo de documento:
Artigo
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