Hyalinizing trabecular adenoma--a case report with FNAC histologic, MIB-1 proliferative index and immunohistochemical findings.
Indian J Pathol Microbiol
;
1998 Oct; 41(4): 479-84
Artigo
em Inglês
| IMSEAR
| ID: sea-73004
ABSTRACT
Hyalinizing trabecular adenoma is a recently described benign thyroid tumor, almost exclusively occurring in females. The morphological features of this entity overlap with both papillary and medullary carcinoma to varying extent. This, in turn, creates a situation of serious diagnostic pitfall particularly for a false positive diagnosis of papillary carcinoma in fine needle aspiration (FNA) cytology. False consideration of medullary carcinoma is also possible by the unwary especially if staining for Congo red and/or immunostaining for calcitonin is not resorted to. At histologic level, the distinctive architectural pattern is however of great help and thus poses a much lesser danger of misdiagnosis. We relate here our experience in a recently encountered case of hyalinizing trabecular adenoma and describe detailed FNA cytologic and histologic findings along with immunohistochemical profile using a panel of eight monoclonal antibodies. The tumor proliferative potential has also been assessed using MIB-1 (Ki-67) immunostaining. The various pros and cons of diagnostic pitfalls are discussed.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Glândula Tireoide
/
Biópsia por Agulha
/
Feminino
/
Humanos
/
Neoplasias da Glândula Tireoide
/
Imuno-Histoquímica
/
Carcinoma Papilar
/
Adenoma
/
Divisão Celular
/
Carcinoma Medular
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
1998
Tipo de documento:
Artigo
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