Endometrial intraepithelial carcinoma: a case report and brief review.
Indian J Pathol Microbiol
;
2008 Oct-Dec; 51(4): 512-4
Artigo
em Inglês
| IMSEAR
| ID: sea-73042
ABSTRACT
This case report describes the precursor lesion of uterine papillary serous carcinoma (UPSC). A 65-year-old post-menopausal female presented with prolapse and vaginal discharge and underwent a hysterectomy revealing an atrophic endometrium, highly atypical endometrial glands, the lining cells of which showed pseudostratification, hobnailing, a high nuclear to cytoplasmic ratio, and prominent nucleoli. A p53 immunoreactivity score of 8 and a MIB-1 index of 80% was obtained leading to a diagnosis of endometrial intraepithelial carcinoma (EIC). Since serous EIC is commonly associated with extra-uterine serous carcinoma, it is a uniquely aggressive precursor lesion. Molecular studies support the hypothesis that EIC is a precursor of both uterine and extra-uterine invasive serous carcinomas. This is why the treatment protocol for EIC cases is total abdominal hysterectomy (TAH), accompanied by a staging procedure. In our patient, EIC was limited to the endometrium; associated with an excellent clinical outcome.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Lesões Pré-Cancerosas
/
Neoplasias Uterinas
/
Idoso
/
Feminino
/
Humanos
/
Carcinoma in Situ
/
Carcinoma Papilar
/
Proteína Supressora de Tumor p53
/
Neoplasias do Endométrio
/
Endométrio
Tipo de estudo:
Guia de Prática Clínica
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2008
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS