Neonatal hepatitis--an autopsy study of 14 cases.
Indian J Pathol Microbiol
;
1998 Jan; 41(1): 77-84
Artigo
em Inglês
| IMSEAR
| ID: sea-73182
ABSTRACT
Fourteen autopsy cases of neonatal hepatitis have been studied. Of these seven cases were due to infections viz. cytomegalovirus infection (four cases), probable cases of congenital syphilis (two cases) and neonatal herpes (one case). The remaining seven cases were of Idiopathic Neonatal Hepatitis (INH) with giant cell change in six cases. Even in these cases (INH) there was a high index of suspicion of intrauterine or acquired infection in view of severe mononuclear inflammation in the pancreas, alimentary tract and lungs. Most of these neonates with INH had low birth weight and two were preterm pointing towards a prenatal insult. The orcein stain and Periodic Acid Schiff (PAS) with diastase in all the cases were negative making hepatitis B virus infection and infinity 1 antitrypsin deficiency less likely. These autopsies represent the tip of the iceberg and only the severe cases of infection. The fatal outcome could have been prevented by maternal screening for infections and earlier clinical diagnosis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Autopsia
/
Coloração e Rotulagem
/
Sífilis Congênita
/
Feminino
/
Humanos
/
Masculino
/
Recém-Nascido
/
Células Gigantes
/
Infecções por Herpesviridae
/
Hepatite
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
1998
Tipo de documento:
Artigo
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