MHC non -HLA gene polymorphisms in transplantation.
Indian J Pathol Microbiol
;
2007 Oct; 50(4): 881-5
Artigo
em Inglês
| IMSEAR
| ID: sea-73650
ABSTRACT
Despite many studies on non-HLA genetic polymorphism its role in transplantation is still not well understood. The NK cell receptor gene, MICA gene and Minor histocompatibility (mHag) system makes the puzzle still more intriguingly complex. Studies on cytokine gene polymorphism have enlightened some interesting associations such as the effect of donor IL-6 genotype on acute rejection in renal transplantation. In the bone marrow transplant where each polymorphism is taken as a risk factor for GVHD necessitates prospective testing of non-HLA gene polymorphism and hence, transplant outcome. Various typing methods are now available to identify the non-HLA genetic polymorphisms. A scenario can be envisaged where polymorphisms associated with transplant outcome are tested prior to transplantation at the same time as HLA typing.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polimorfismo Genético
/
Humanos
/
Antígenos de Histocompatibilidade Menor
/
Citocinas
/
Repetições de Microssatélites
/
Rejeição de Enxerto
/
Antígenos de Histocompatibilidade
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2007
Tipo de documento:
Artigo
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