P 53 and PCNA in Non Hodgkin's lymphoma--an immunohistochemical evaluation.
Indian J Pathol Microbiol
;
2000 Jan; 43(1): 61-4
Artigo
em Inglês
| IMSEAR
| ID: sea-73747
ABSTRACT
P 53 positivity and PCNA labelling index were studied in 50 cases of node based Non Hodgkin's lymphomas, P 53 positivity was observed in a spectrum of these disorders, suggesting that P 53 mutations play a role in the genesis of these tumours. P 53 positivity incresed from low through intermediate to high grade tumours and thus may be of prognostic value in these lesions. PCNA labelling index (LI) was higher in high grade tumours. P 53 and PCNA immunoreactivity showed a relationship in that PCNA LI was seen to be more than 30% in P 53 positive tumours. P 53 positivity appears to be related to the subtype and proliferation rate of NHL.
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Índice:
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Assunto principal:
Prognóstico
/
Linfoma não Hodgkin
/
Humanos
/
Imuno-Histoquímica
/
Proteína Supressora de Tumor p53
/
Antígeno Nuclear de Célula em Proliferação
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2000
Tipo de documento:
Artigo
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