Retinoblastoma--a histologic and immunohistologic study.
Indian J Pathol Microbiol
;
1997 Jan; 40(1): 37-46
Artigo
em Inglês
| IMSEAR
| ID: sea-73993
ABSTRACT
Histopathology and various immunohistochemical markers were studied in 40 cases of human retinoblastoma. In histopathology, tumour type, extent and invasion were studied. In immunohistochemistry, both glial and neural markers were used to know the histogenesis of this tumour. The glial markers, glial fibrillary acidic protein and vimentin, were detected in retinal astrocytes and Muller's cells in normal retina and perivascular glia in retinoblastoma. The neural marker, neurone-specific enolase stained neurones in outer and inner nuclear layers in normal retina, Flexner-Wintersteiner rosettes in retinoblastoma and tumour cells is differentiated retinoblastoma. Another neural marker, neurofilament triplet polypeptide stained neurones in inner nuclear layer of normal retina and Flexner-Wintersteiner rosettes in well-differentiated retinoblastoma. These results support the view that retinoblastoma has predominantly neuronal origin.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Fosfopiruvato Hidratase
/
Retinoblastoma
/
Vimentina
/
Feminino
/
Humanos
/
Masculino
/
Imuno-Histoquímica
/
Biomarcadores Tumorais
/
Criança
/
Pré-Escolar
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
1997
Tipo de documento:
Artigo
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