Adverse drug reactions in pediatrics with a study of in-hospital intensive surveillance.
Indian Pediatr
;
1993 Jun; 30(6): 745-51
Artigo
em Inglês
| IMSEAR
| ID: sea-7426
ABSTRACT
A two-part prospective study of adverse drug reactions (ADRs) in Indian children was carried out at a teaching general hospital. Using an in-hospital intensive surveillance scheme (IISS) for the detection of ADRs, indoor patients of one of the two units in the pediatric ward were monitored daily for 6 months, with the other unit serving as a control group. A total of 347 patients were monitored, 2781 daily orders written and 24,474 doses of 96 different drugs given. Six patients suffered from ADRs (1.73%), and 1 reaction proved fatal (0.29%), while the control group reported only 1 ADR in the same time period. The frequency of ADRs (p < 0.001) and their resultant mortality in Indian children was less than that in a western prototype study. Though IISS showed a marked increase in ADR reporting, it was too cumbersome for routine use in our country. In the second part of the study, 40 cases of ADRs seen over 2 years were analyzed. Antimicrobials, especially sulphonamides, accounted for a high percentage of cases mostly as skin rashes and fairly severe reactions were common. Patients on anti-tuberculous and anti-convulsant drugs required prolonged supervision for late onset reactions.
Texto completo:
DisponíveL
Índice:
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Assunto principal:
Algoritmos
/
Feminino
/
Humanos
/
Masculino
/
Recém-Nascido
/
Criança
/
Pré-Escolar
/
Projetos Piloto
/
Incidência
/
Causalidade
Tipo de estudo:
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
1993
Tipo de documento:
Artigo
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