Proliferating cell nuclear antigen immunostaining in breast carcinoma and its relationship to clinical and pathological variables.
Indian J Pathol Microbiol
;
1997 Jan; 40(1): 11-6
Artigo
em Inglês
| IMSEAR
| ID: sea-74468
ABSTRACT
Tumour proliferative activity of 74 breast lesions was assessed by determining mitotic index and immunostaining for proliferative cell nuclear antigen using Peroxidase antiperoxidase method. The indices were correlated with histomorphology and clinical stage of the disease. Positively stained nuclei and mitotic figures were counted per 1000 cells to calculate Proliferating Cell Nuclear Antigen (PCNA) and mitotic index respectively. Sixty four cases stained positive for PCNA. The index ranged between 0 to 98. PCNA index was significantly low in benign lesions as compared to malignant lesions (p < 0.0002). There was a linear correlation between the mitotic index and PCNA index. PCNA index also showed significant correlation with tumour size and histologic grade; however, it had no correlation with axillary lymph node status.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Neoplasias da Mama
/
Feminino
/
Humanos
/
Imuno-Histoquímica
/
Carcinoma
/
Antígeno Nuclear de Célula em Proliferação
/
Metástase Linfática
/
Índice Mitótico
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
1997
Tipo de documento:
Artigo
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