Morphometric study of lymphoid cells in mycosis fungoides and its simulators.
Indian J Pathol Microbiol
;
2003 Jan; 46(1): 28-33
Artigo
em Inglês
| IMSEAR
| ID: sea-74532
ABSTRACT
The distinction of early stages of mycosis fungoides from benign lymphoid disorders of skin is difficult by conventional histological techniques. We studied 10 cases of mycosis fungoides, 10 cases of large plaque parapsoriasis, 10 cases of other benign lymphoid disorders of skin and 5 cases of lymph nodes. Nuclear area, perimeter of the nucleus, nuclear contour index, cytoplasmic area, form factor and nuclear cytoplasmic ratio as well as DNA-ploidy were determined by image analysis. There were statistically significant difference (P value < 0.05) between all parameters except nuclear cytoplasmic ratio of the lymphoid cells of Mycosis Fungoides and benign lymphoid disorders of skin. Aneuploidy was found in 50% cases of Mycosis Fungoides. Histopathological parameters like epidermotropism pautrier micro-abscess and atypical lymphocytic infiltrate in both epidermis and dermis were more marked in aneuploid than diploid cases. So, the determination of nuclear contour index and DNA-ploidy is of importance to differentiate between Mycosis Fungoides and benign lymphoid disorders of skin.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Ploidias
/
Neoplasias Cutâneas
/
Feminino
/
Humanos
/
Masculino
/
DNA de Neoplasias
/
Linfócitos
/
Estudos Retrospectivos
/
Micose Fungoide
/
Adulto
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2003
Tipo de documento:
Artigo
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