Comparative evaluation of cell proliferative indices and epidermal growth factor receptor expression in gastric carcinoma.
Indian J Pathol Microbiol
;
1997 Oct; 40(4): 481-90
Artigo
em Inglês
| IMSEAR
| ID: sea-74698
ABSTRACT
A total of 62 patients of gastric carcinoma were studied to find a correlation between newer prognostic indicators like cell proliferative indices including Nucleolar Organizer regions (AgNORs), Ki 67 Labelling Index and Epidermal Growth Factor Receptor (EGFR) expression with the various, histopathological criteria and compared with 30 controls of non neoplastic gastric diseases. EGFR expression was positive in 48(77.4%) cases. The Ki 67 labelling indices ranged from 0 to 50% with a mean of 21.35 +/- 17.88% among the cases. AgNOR counts ranged from 1.64 to 4.49 with a mean of 3.41 +/- 0.81 among the cases. Positive EGFR expression correlated strongly with differentiation of the tumour, poorly differentiated tumours showing a higher positivity. EGFR positivity also showed good correlation with metastasis as well as with the invasiveness of the tumour. Ki 67 labelling indices correlated significantly with metastatic status, microscopic types and degree of differentiation of the tumour. A strong correlation was observed between AgNOR counts and metastasis as well as the microscopic type of the tumour. EGFR expression correlated strongly with Ki 67 scores and weakly with AgNOR counts among the patients of gastric carcinoma.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Prognóstico
/
Gastropatias
/
Neoplasias Gástricas
/
Humanos
/
Biomarcadores Tumorais
/
Antígeno Ki-67
/
Receptores ErbB
/
Índice Mitótico
/
Invasividade Neoplásica
/
Metástase Neoplásica
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
1997
Tipo de documento:
Artigo
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