Immune complex mediated lesions in experimental Kala azar: an ultrastructural study.
Indian J Pathol Microbiol
;
2000 Jan; 43(1): 13-6
Artigo
em Inglês
| IMSEAR
| ID: sea-74865
ABSTRACT
Immune complexes play an important role in causation of renal lesions in various diseases. Circulating immune comlexes (CIC) are described in Kala azar. Role of CIC in pathogenesis of Kalaazar is discussed in present study. BALB/C mice were experimentally infected with L. donovani promastigotes. After visceralisation of infection, sera and kidneys of infected mice were preserved. Leishmanial antigen specific CIC could be demonstrated in 100% of infected mice by PEG ELISA, while they were absent in control mice. Ultrastructural pattern of renal lesions in infected mice showed presence of focal small electron dense deposits in glomerular basement membrane and subepithelial space, resembling immune complexes (humps). Rarely subendothelial and mesangial hypercellularity was present. These findings point towards a definite role of CIC in pathogenesis of renal lesions in Kalaazar.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Leishmania donovani
/
Ensaio de Imunoadsorção Enzimática
/
Rim
/
Glomérulos Renais
/
Leishmaniose Visceral
/
Animais
/
Camundongos
/
Camundongos Endogâmicos BALB C
/
Complexo Antígeno-Anticorpo
/
Antígenos de Protozoários
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2000
Tipo de documento:
Artigo
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