Acute erythroid toxicity in visceral leishmaniasis: a rare complication of antimonial therapy.
Indian J Pathol Microbiol
;
2008 Oct-Dec; 51(4): 546-7
Artigo
em Inglês
| IMSEAR
| ID: sea-74885
ABSTRACT
The spectrum of side-effects of sodium stibogluconate is well described, however, little is known regarding the acute erythroid toxicity caused by this drug. We hereby present a case with this unusual complication of antimonial therapy. A 6-year-old male with leishmaniasis was started on parenteral sodium stibogluconate. During the course of treatment, his hemoglobin (Hb) dropped from 7.2 g/dl to 3.5 g/dl. Bone-marrow aspirate showed karyorrhexis in many erythroid precursors with several Leishmania donovanii bodies. Sodium stibogluconate was stopped and amphotericin-B was started. Four days after the cessation of the antimonials, the patient's Hb improved to 5 gm/dl with a corrected reticulocyte count of 10% indicating bone-marrow erythroid regeneration. The exact mechanism of this acute erythroid toxicity of sodium stibogluconate remains unexplored.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Leishmania donovani
/
Humanos
/
Masculino
/
Criança
/
Gluconato de Antimônio e Sódio
/
Células Eritroides
/
Leishmaniose Visceral
/
Animais
/
Antiprotozoários
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2008
Tipo de documento:
Artigo
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