Serum lactate dehydrogenase isoenzymes in breast tumours.

ABSTRACT

Total serum LDH and its isoenzymes were estimated in 10 female controls and 30 cases of breast lump (22 malignant, 6 benign and 2 breast abscess). In breast malignancy, there was a significant elevation of total LDH and LDH-3, LDH-4 and LDH-5 isoenzymes with a significant fall in LDH-1 and LDH-2 percentage value. Following therapy, there was a significant elevation in LDH-1 and LDH-2 towards normal with a significant fall in total serum LDH and LDH-4 and LDH-5 isoenzymes. The estimation was found to be helpful in assessing the response of patient to the therapy given.