Is seroprevalence of anti-IGM CMV among blood donors relevant in India?
Artigo
em Inglês
| IMSEAR
| ID: sea-75229
ABSTRACT
BACKGROUND:
Infection with cytomegalovirus (CMV) is more common in developing nations and the people belonging to the lower socioeconomic section of the society. The immunosuppressed population for whom CMV-seronegative blood products are requested is increasing due to advances in medical care.AIM:
To study the prevalence of CMV antibodies among the different sexes and age groups in healthy blood donors. MATERIALS ANDMETHODS:
A retrospective study was done on 5600 serum samples stored frozen in a repository for CMV antibodies using the ELISA technique.RESULTS:
Five thousand three hundred and fifty (95.5%) were male and 250 (4.5%) were female. Four cases (0.071%) out of 5600 samples were positive for anti-IgM CMV with 95% Confidence Interval (95% C.I) of 0.02 - 0.17.CONCLUSION:
In a developing country like India, screening for IgM antibody on a routine basis may not be feasible, given the likely positive yield to be low and the cost being high. It is recommended that in a tertiary care hospital, blood units to be transfused to neonates, organ transplant recipients, those suffering from malignancies and other immunocompromised patients should be screened for anti-IgM CMV or preventive strategies like universal leucodepletion to be implemented to decrease the transmission of CMV in these groups of patients.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Doadores de Sangue
/
Feminino
/
Humanos
/
Masculino
/
Imunoglobulina M
/
Ensaio de Imunoadsorção Enzimática
/
Estudos Soroepidemiológicos
/
Estudos Retrospectivos
/
Adolescente
/
Infecções por Citomegalovirus
Tipo de estudo:
Estudo observacional
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Ano de publicação:
2008
Tipo de documento:
Artigo
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