Effect of vitamin C deficiency and excess on the liver: a histopathological and biochemical study in guinea pigs fed normal or high cholesterol diet.
Indian J Pathol Microbiol
;
1990 Oct; 33(4): 307-13
Artigo
em Inglês
| IMSEAR
| ID: sea-75512
ABSTRACT
When guinea pigs were kept on a restricted vitamin C intake of only 0.5 mg daily, their serum ascorbic acid fell to 0.16 +/- 0.06 mg/d1 in 16 weeks as compared to 0.73 +/- 0.11 in control. This was associated with significant increase in liver cholesterol and triglycerides. When they were simultaneously challenged with a high cholesterol load, this fat accumulation was markedly exaggerated. The weight of the liver now increased by almost two-and-half times. Liver cholesterol rose to 12.90 +/- 2.63 mg/gm as compared to 3.23 +/- 0.56 mg/gm with low vitamin C alone. Histopathology showed marked distension and vacuolation of hepatocytes, focal necrosis and fibroplasia. Administration of excess vitamin C (100 mg daily) significantly countered these changes. The vitamin C-lipid relationship has important clinical bearings and liver could be an important site of vitamin C action.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Tamanho do Órgão
/
Ácido Ascórbico
/
Deficiência de Ácido Ascórbico
/
Triglicerídeos
/
Masculino
/
Colesterol na Dieta
/
Colesterol
/
Cobaias
/
Fígado
/
Animais
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
1990
Tipo de documento:
Artigo
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