Red cell alloimmunization in multi-transfused chronic renal failure patients undergoing hemodialysis.
Indian J Pathol Microbiol
;
1999 Jul; 42(3): 299-302
Artigo
em Inglês
| IMSEAR
| ID: sea-75727
ABSTRACT
Red blood cell (RBC) transfusions are frequently used in the management of patients with chronic renal failure (CRF) undergoing hemodialysis for dialysis-related anaemia. Consequently, they are subject to all hazards associated with repeated transfusions, such as red cell alloimmunization. A retrospective study was performed to estimate the frequency of alloimmunization against red cell antigens in multitransfused CRF patients. A total of 81 patients (67 males & 14 females) with CRF were studied who received a mean of 8.5 units of RBC matched for ABO & Rh(D) antigens only. Using standard techniques (indirect antiglobulin test, enzyme, polyethylene glycol, and low ionic strength solution), we observed a RBC alloimmunization rate of 9.8% (8/81). Nine alloantibodies were detected in 8 patients, and most (88%) involved antigens in the Rhesus & Kell systems. No correlation was observed with the alloantibody formation & number of units transfused. The calculated risk of 1.3% observed in the present study, suggests that renal failure patients are not at a higher risk of red cell alloimmunization than the general population.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Estudos Retrospectivos
/
Diálise Renal
/
Imunização
/
Transfusão de Eritrócitos
/
Adulto
/
Eritrócitos
/
Isoanticorpos
Tipo de estudo:
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
1999
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS