Apoptosis in premalignant and malignant squamous cell lesions of the oral cavity: a light microscopic study.
Indian J Pathol Microbiol
;
2009 Apr-Jun; 52(2): 164-6
Artigo
em Inglês
| IMSEAR
| ID: sea-75910
ABSTRACT
BACKGROUND:
Oral cancers are a major health problem in India. Recently, parameters of cell proliferation and cell death have emerged as important diagnostic and prognostic tools.AIMS:
The aim was to study apoptosis in premalignant and malignant squamous cell lesions of the oral cavity and to evaluate its prognostic role in oral cancers. MATERIALS ANDMETHODS:
The study included 175 patients presenting with oral lesions. Evaluation of apoptotic index (AI) (using light microscopy) was performed on hematoxylin and eosin-stained sections. STATISTICAL ANALYSIS USED Student's t test was performed.RESULTS:
The mean AI increased progressively with increasing dysplasia, with the maximum AI in well-differentiated (WD) squamous cell carcinoma, and a fall was noted with progression toward higher grades. The difference between WD SCC and poorly-differentiated SCC was significant (P < 0.05). Cases with lymph node metastasis had significantly (P < 0.05) lower mean AI values.CONCLUSION:
Apoptosis can be fairly accurately assessed using light microscopy. Tumors that exhibit less apoptosis tend to show aggressive behavior and have a greater potential for metastasis.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2009
Tipo de documento:
Artigo
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