AML1-ETO positive AML: first report from India.
Indian J Pathol Microbiol
;
2007 Jul; 50(3): 652-4
Artigo
em Inglês
| IMSEAR
| ID: sea-75916
ABSTRACT
Translocation (8;21) is associated with few typical morphological features and favorable prognosis. All patients of AML and MDS with increased blasts (N = 35) according to FAB criteria, presenting (between Jan 2004 to June 2005) to the Department of Hematology, AIIMS were studied. RT-PCR was done for the AML1-ETO fusion transcript in all cases. Overall incidence of AML1-ETO was 28.57% and no correlation was found between AML1-ETO positivity and clinical or hematological parameters except for a direct correlation with absolute blast count (ABC) (a lower ABC in the AML1-ETO positive cases). Interestingly, 1/3 MDS cases were positive for the same fusion transcript and thus, it appears worthwhile to look for AML1-ETO in all cases of MDS with increased blasts. Objective morphological evaluation using a scoring system based on morphological features was not helpful in predicting positivity for AML1-ETO. The effect of this translocation on long-term survival could not be determined by the present study.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Translocação Genética
/
Síndromes Mielodisplásicas
/
Cromossomos Humanos Par 8
/
Cromossomos Humanos Par 21
/
Idoso
/
Feminino
/
Humanos
/
Masculino
/
Leucemia Mieloide Aguda
/
Proteínas de Fusão Oncogênica
Tipo de estudo:
Estudo de incidência
/
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Pathol Microbiol
Ano de publicação:
2007
Tipo de documento:
Artigo
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