Urinary N-acetyl-beta-D-glucosaminidase activity in type I diabetes mellitus.
Indian Pediatr
;
2003 May; 40(5): 410-4
Artigo
em Inglês
| IMSEAR
| ID: sea-7682
ABSTRACT
We measured urinary albumin excretion rate (AER) and N-acetyl-beta-D-glucosaminidase (NAG) activity in relation to disease duration, acetylated hemoglobin (HbA1c), hypertension and puberty in 44 children and adolescents with type 1 diabetes mellitus. AER and Urinary NAG activity were significantly higher in the patients compared to controls (AER 19.4 +/-; 35.8 vs 4.7 +/- 4.4, NAG activity 5.6 +/- 0.6U vs. 1.6 +/- 0.2U). Microalbuminuria was present in seven patients (15.9%), all of whom were pubertal. There was no correlation between AER and urinary NAG activity. There was a significant direct correlation between AER and disease duration (P <0.05), HbA1c (P < 0.05), diastolic blood pressure (P <0.05) and puberty (P <0.05). None of the microalbuminuria related variables was significantly correlated with urinary NAG activity. Puberty was an independent factor for elevated urinary NAG activity. This study shows that urinary NAG is elevated in children and adolescents with type 1 diabetes mellitus, but is not associated with AER related factors except for puberty. Urinary NAG activity does not appear to be a useful marker for early detection of diabetic nephropathy in children and adolescents with type 1 diabetes mellitus.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Acetilglucosaminidase
/
Feminino
/
Humanos
/
Masculino
/
Criança
/
Adolescente
/
Adulto
/
Diabetes Mellitus Tipo 1
Tipo de estudo:
Estudo de rastreamento
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2003
Tipo de documento:
Artigo
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