Early onset conjugated hyperbilirubinemia in newborn infants.
Indian J Pediatr
;
2006 May; 73(5): 409-12
Artigo
em Inglês
| IMSEAR
| ID: sea-78865
ABSTRACT
OBJECTIVES:
To determine the causes and related outcomes of early onset conjugated hyperbilirubinemia in a group of newborn infants and to determine the incidence of sepsis in these neonates.METHODS:
The charts of 42 babies with conjugated hyperbilirubinemia were retrospectively reviewed.RESULTS:
The mean gestational age was 37 weeks and the mean postnatal age at presentation was 10 days. Culture-proven sepsis was identified in 15 babies (35.7% of total). Gram-negative bacteria were isolated in 10 cases and E. coli was the most common of these agents (7 cases). Perinatal hypoxia-ischemia was the second most frequent etiology (7 patients; 16.7% of total). The other diagnoses were blood group incompatibility (n=5), Down syndrome (n=3), cholestasis associated with parenteral nutrition (n=3), neonatal hepatitis (n=2), metabolic liver disease (n=1), biliary atresia (n=1), portal venous thrombosis (n=1) and unknown (n=4). Thirteen babies with sepsis recovered completely with treatment, whereas the prognosis for those with perinatal hypoxia-ischemia was grave (six of seven died).CONCLUSIONS:
The findings suggest that early onset cholestatic jaundice in newborn infants is more commonly from non-hepatic causes, so it is reasonable to monitor these infants carefully for a period of time before undertaking time-consuming or invasive investigations towards a primary liver disease.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Recém-Nascido
/
Incidência
/
Estudos Retrospectivos
/
Idade de Início
/
Sepse
/
Hiperbilirrubinemia Neonatal
Tipo de estudo:
Estudo de incidência
/
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
2006
Tipo de documento:
Artigo
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