Dysfunction of innate immunity and associated pathology in neonates.
Indian J Pediatr
;
2007 Feb; 74(2): 185-91
Artigo
em Inglês
| IMSEAR
| ID: sea-78927
ABSTRACT
The neutrophils and complement system are the critical elements of innate immunity mainly due to participation in the first line of defense against microorganisms by means of phagocytosis, lysis of bacteria and activation of naive B-lymphocytes. In this report we provide an overview of the up to date information regarding the neutrophil and complement system's functional ability in newborn infants in association with the maternal conditions that exist during the intrauterine stage, gestational age and post-neonatal pathology. The neonates' capacity to control the neutrophil and complement protein activation process has also been discussed because of the evidence that uncontrolled activation of these immune elements provides a significant contribution to the tissue damage and subsequent pathology. The authors are confident that despite the many unanswered questions this review updates their knowledge and points the need for further research to clarify the role of the age-associated dysfunction of neutrophils and complement system in the infection and inflammation related pathology of newborn infants.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Proteínas do Sistema Complemento
/
Recém-Nascido
/
Fatores de Risco
/
Sensibilidade e Especificidade
/
Imunidade Materno-Adquirida
/
Imunidade Inata
/
Neutrófilos
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
2007
Tipo de documento:
Artigo
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