Treatment of patients with haemophilia and inhibitory antibodies.
Indian J Pediatr
;
2003 Aug; 70(8): 655-9
Artigo
em Inglês
| IMSEAR
| ID: sea-79512
ABSTRACT
The development of inhibitory antibodies is a complication which arise in approximately 10% of patients with haemophilia A. The underlying genetic mutation is the single most important predisposing cause, although other risk factors have been identified. Periodic screening for inhibitors is a vital aspect of haemophilia care. The consequences of inhibitor development are very significant in terms of morbidity and cost. Several agents are now available for control of bleeding, but these are often very expensive. The most useful agents include recombinant activated factor VII, prothrombin complex concentrates and porcine factor VIII. It is possible to suppress antibody production with immune tolerance, which is successful in approximately 85% of cases and relapse is rare.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Fatores de Coagulação Sanguínea
/
Fator VIII
/
Fator VIIa
/
Criança
/
Pré-Escolar
/
Inibidores dos Fatores de Coagulação Sanguínea
/
Predisposição Genética para Doença
/
Hemofilia A
/
Tolerância Imunológica
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
2003
Tipo de documento:
Artigo
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