Strategies for minimizing corticosteroid toxicity: a review.
Indian J Pediatr
;
2008 Oct; 75(10): 1067-73
Artigo
em Inglês
| IMSEAR
| ID: sea-79519
ABSTRACT
Glucocorticoids (GCs) are used commonly for the treatment of various pediatric inflammatory and autoimmune diseases. Although potent and generally effective, they are not without risks for producing serious adverse effects, especially when used in high doses for prolonged periods of time. For proper use of systemic glucocortcoids, a basic knowledge of the pharmacology, clinical usage guidelines, and adverse reactions of these agents is imperative. This review article emphasis on the commonly observed side-effects encountered with GC use in children and their underlying basic pathophysiological mechanisms. The appropriate anticipation of these side-effects with timely implementation of the suggested evidencebased guidelines has the potential significantly to prevent, minimize and treat common and disabling complications of glucocortcoid therapy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Humanos
/
Esquema de Medicação
/
Corticosteroides
/
Insuficiência Adrenal
/
Glândulas Suprarrenais
/
Medição de Risco
/
Relação Dose-Resposta Imunológica
/
Glucocorticoides
/
Sistema Hipotálamo-Hipofisário
Tipo de estudo:
Estudo de etiologia
/
Guia de Prática Clínica
/
Fatores de risco
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
2008
Tipo de documento:
Artigo
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