Liver biopsies in patients with lysosomal storage disease: experience with effective sedation.
Indian J Pediatr
;
1997 Nov-Dec; 64(6): 887-91
Artigo
em Inglês
| IMSEAR
| ID: sea-79567
ABSTRACT
We prospectively applied a protocol used to sedate children who required a liver biopsy. Sixty liver biopsies were performed on thirty pediatric patients to assess the effects of treatment. Sixteen patients had Type 1 Gaucher's disease of which seven had a platelet count between 50-100,000/mm3. All seven had bleeding time performed and when indicated, intravenous DDAVP (1-deamino-8-D-arginine vasopressin) was used to improve hemostasis. Fourteen patients had Niemann-Pick disease type C of which eight were significantly demented and uncooperative. Before liver biopsy, all patients were sedated with the following regimen oral chlorpromazine (1 mg/kg) followed one hour later by intravenous meperidine (1 mg/kg) and pentobarbital (maximum dosage 6 mg/kg) administered by slow intravenous injection. Liver biopsies were obtained safely on all patients. Only 1 patient (2%) developed a potentially serious complication an obstructed airway which was readily corrected by simple repositioning. Transient less serious complications occurred in another 7 patients (12%). There was no long term sequalae of the biopsy procedures. Our study indicates that with appropriate patient selection, this sedation protocol may be useful in pediatric patients requiring a liver biopsy.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Biópsia por Agulha
/
Feminino
/
Humanos
/
Masculino
/
Criança
/
Pré-Escolar
/
Estudos Prospectivos
/
Sedação Consciente
/
Sensibilidade e Especificidade
/
Adolescente
Tipo de estudo:
Estudo diagnóstico
/
Guia de Prática Clínica
/
Estudo observacional
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
1997
Tipo de documento:
Artigo
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