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Familial combined hyperlipidemia in a North Indian kindred.
Indian J Pediatr ; 2005 Nov; 72(11): 987-9
Artigo em Inglês | IMSEAR | ID: sea-79634
ABSTRACT
Familial combined hyperlipidemia is the most common genetic hyperlipidemia and is responsible for premature coronary artery disease. It is genetically heterogenous and no single diagnostic marker exists. The authors report an affected North Indian kindred spanning three successive generations with a possible autosomal dominant pattern of inheritance and all of them had combined dyslipidemia [elevated total cholesterol, predominantly the low density lipoprotein (LDL) fraction and elevated triglycerides]. The proband, a 4-month-old male baby, was incidentally discovered to have a lipaemic serum and so further evaluated. Both the index case and his maternal grandmother, a non-obese diabetic (type 2) with hypertension, had an atherogenic lipoprotein phenotype. Lipaemia retinalis was documented in this baby but xanthomas and coronary artery disease were not noted in the kindred. The present case report highlights the failure of dietary therapy in the proband and explores new options.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Triglicerídeos / Humanos / Masculino / Colesterol / Hiperlipidemia Familiar Combinada / Índia / Lactente País/Região como assunto: Ásia Idioma: Inglês Revista: Indian J Pediatr Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Triglicerídeos / Humanos / Masculino / Colesterol / Hiperlipidemia Familiar Combinada / Índia / Lactente País/Região como assunto: Ásia Idioma: Inglês Revista: Indian J Pediatr Ano de publicação: 2005 Tipo de documento: Artigo