Leukocyte adhesion deficiency type 1 presenting as leukemoid reaction.
Indian J Pediatr
;
2007 Dec; 74(12): 1121-3
Artigo
em Inglês
| IMSEAR
| ID: sea-80098
ABSTRACT
Leukocyte Adhesion Deficiency (LAD) is characterized by the inability of leukocytes, in particular neutrophilic granulocytes, to emigrate from the blood stream towards sites of inflammation. Infectious foci are nonpurulent and may eventually become necrotic because of abnormal wound healing. LAD-I is characterized by the absence of the beta-2 integrins CD II and CD 18 on leukocytes. We present a male neonate referred with continuation of leukemoid reaction in spite of antibiotic therapy of simultaneous omphalitis. The diagnosis of LAD-I was confirmed by flow cytometry, showing a deficiency of beta-2 integrins on the surface of the leukocytes. After management, the patient was discharged with prophylactic antibiotics.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Infecções Bacterianas
/
Humanos
/
Masculino
/
Recém-Nascido
/
Síndrome da Aderência Leucocítica Deficitária
/
Antibioticoprofilaxia
/
Diagnóstico Diferencial
/
Reação Leucemoide
/
Antibacterianos
Tipo de estudo:
Estudo diagnóstico
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
2007
Tipo de documento:
Artigo
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