Beta-thalassemias: expression, molecular mechanisms and mutations in Indians.
Indian J Pediatr
;
1998 Nov-Dec; 65(6): 815-23
Artigo
em Inglês
| IMSEAR
| ID: sea-80678
ABSTRACT
The beta-thalassemias are a heterogenous group of inherited disorders of hemoglobin (Hb) synthesis characterized by a reduction (beta+) or absence (beta zero) of synthesis of the beta globin chains of Hb, resulting in an imbalanced chain synthesis. To understand their expression and molecular basis in Indians, it is essential to review briefly the genetic control of normal Hb production and the structure, organization and regulation of different globin genes. The Indian beta-thalassemia mutations and strategies for prevention are described.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Cromossomos Humanos Par 11
/
Humanos
/
Globinas
/
Criança
/
Talassemia beta
/
Países em Desenvolvimento
/
Índia
/
Mutação
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
1998
Tipo de documento:
Artigo
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