Liver transplantation in children.
Indian J Pediatr
;
2002 Feb; 69(2): 175-83
Artigo
em Inglês
| IMSEAR
| ID: sea-80879
ABSTRACT
The results of liver transplantation has improved significantly in the last decade with one year survival figures close to 90% for children with chronic liver disease. This can be attributed to improvement in surgical techniques, better postoperative care and newer immunosuppresive drugs. As a result of this, increasing number of children are referred for transplantation with no significant increase in the number of solid organ donors. The earliest transplants in children were performed using organs from size matched pediatric donors. However, as the pediatric donor numbers were limited, liver reduction techniques were developed to transplant small children before deterioration. Increasing experience with reduced livers led to the development of split liver, living donor and auxiliary liver transplantation. Better management of immunosuppressive drugs and newer agents such as Mycophenolate Mofetil have reduced the incidence of graft loss due to chronic rejection and long-term renal toxicity. The goal for the future will remain to be transplantation without the use of long-term immunosuppression.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Complicações Pós-Operatórias
/
Prognóstico
/
Feminino
/
Humanos
/
Masculino
/
Criança
/
Pré-Escolar
/
Fatores de Risco
/
Transplante de Fígado
/
Medição de Risco
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
/
Fatores de risco
País/Região como assunto:
Europa
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
2002
Tipo de documento:
Artigo
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