Serum alpha feto-protein screening in high risk pregnancies.
Indian J Pediatr
;
1995 Jan-Feb; 62(1): 101-7
Artigo
em Inglês
| IMSEAR
| ID: sea-81010
ABSTRACT
We assayed alpha fetoprotein (AFP) in serum samples from 2,735 women during 14 to 20 weeks of gestation. Serum AFP levels were elevated in the presence of neural tube defect (NTD) and gut atresia in fetus, twin pregnancies, preterm delivery and neonatal complications. In two of the 23 cases of fetal NTD the diagnosis was suggested by AFP assays, with apparently normal ultrasound findings. Low maternal serum AFP levels were associated with chromosomal abnormalities and hydatidiform molar pregnancy. Calculation of risk for Down syndrome based on maternal serum AFP and maternal age helped to reduce the number of women requiring amniocentesis. Maternal serum AFP assay was helpful in the management of threatened abortion, suspected intrauterine death, and maternal toxoplasma infection. In seven cases where maternal serum AFP was high but ultrasound studies were normal, male babies were delivered. Thus maternal serum AFP assay proved useful in narrowing down the group of women requiring more detailed surveillance and diagnostic studies.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Diagnóstico Pré-Natal
/
Anormalidades Congênitas
/
Feminino
/
Humanos
/
Gravidez
/
Biomarcadores
/
Alfa-Fetoproteínas
/
Gravidez de Alto Risco
/
Adulto
/
Doenças em Gêmeos
Tipo de estudo:
Estudo diagnóstico
/
Estudo de etiologia
/
Estudo de rastreamento
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
1995
Tipo de documento:
Artigo
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