Relationship between insulin resistance and serum levels of adiponectin and resistin with childhood obesity.
Indian Pediatr
;
2007 Apr; 44(4): 275-9
Artigo
em Inglês
| IMSEAR
| ID: sea-8265
ABSTRACT
OBJECTIVE:
The aim is to study the relationship between insulin resistance and serum adiponectin and resistin in obese children.METHODS:
A total 113 obese and 37 nonobese children were enrolled and serum adiponectin and resistin were measured.RESULTS:
Compared with controls, higher insulin resistance by homeostasis model (HOMA-IR) and lower whole body insulin resistance index (WBISI)were found in obese children (all P <0.05). The adiponectin levels in obese children and controls were 3.63 and 5.79 microg/L with a significant difference (P<0.001) while the difference of resistin levels was not significant (P = 0.948). Significant correlations between insulin resistance parameter and age,sexual development, BMI, serum triglyceride, ApoB, LDL-cholesterol, HDL-cholesterol, alanine aminotransferase, uric acid, or adiponectin levels (all P <0.05) were noted. Stepwise multiple regression analysis showed that BMI and adiponectin levels were independent determinants of WBISI.CONCLUSIONS:
These results suggest that adiponectin may play a protective role in obese children through decreasing insulin resistance.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Resistência à Insulina
/
Estudos de Casos e Controles
/
Criança
/
China
/
Fatores de Risco
/
Adolescente
/
Adiponectina
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian Pediatr
Ano de publicação:
2007
Tipo de documento:
Artigo
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