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Helicobacter pylori culture and antimicrobial resistance in Iran.
Indian J Pediatr ; 2007 Feb; 74(2): 127-30
Artigo em Inglês | IMSEAR | ID: sea-83298
ABSTRACT

OBJECTIVE:

Helicobacter pylori is considered as an important etiologic factor in pathogenesis of peptic ulcer disease, chronic gastritis and gastric cancer. To eradicate this micro-organism, numerous regimens containing various antimicrobial agents have been suggested. However, H pylori antimicrobial resistance is a leading factor to treatment failure and recurrence of the disease. The aim of the study was to evaluate the prevalence of H pylori resistance to metronidazole, clarithromycin, tetracycline, amoxicillin, erythromycin and furazolidone in authors pediatric patients.

METHODS:

Antral biopsy of all pediatric patients with negative history of receiving anti-H pylori regimen and endoscopic findings of nodular gastritis or peptic ulcer without previous history of NSAID consumption, burning and trauma were performed for H pylori histology, urease test and culture. All positive cultures were tested for antimicrobial susceptibility.

RESULTS:

Twenty four patients (14 male and 10 female) between 3.5 and 14 years of age were culture positive. 54.16% of the isolates were resistant to metronidazole, 8.33% to amoxicillin, 4.16% to erythromycin and 4.16% to clarithromycin. None of authors patients were resistant to tetracycline and furazolidone.

CONCLUSION:

H. pylori antimicrobial resistance could be a major contributor to failure of H pylori eradication. Continuous prospective surveillance of H. Pylori is essential. Moreover, culture and antimicrobial susceptibility test is recommended for resistant cases after the first failure to therapy.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Biópsia por Agulha / Feminino / Humanos / Masculino / Imuno-Histoquímica / Testes de Sensibilidade Microbiana / Criança / Pré-Escolar / Probabilidade / Estudos Prospectivos Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Indian J Pediatr Ano de publicação: 2007 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Biópsia por Agulha / Feminino / Humanos / Masculino / Imuno-Histoquímica / Testes de Sensibilidade Microbiana / Criança / Pré-Escolar / Probabilidade / Estudos Prospectivos Tipo de estudo: Estudo diagnóstico / Estudo de etiologia / Estudo observacional / Estudo prognóstico / Fatores de risco Idioma: Inglês Revista: Indian J Pediatr Ano de publicação: 2007 Tipo de documento: Artigo