Lupus anticoagulant in immune thrombocytopenic purpura.
Indian J Pediatr
;
2004 Jun; 71(6): 505-7
Artigo
em Inglês
| IMSEAR
| ID: sea-83917
ABSTRACT
OBJECTIVE:
Antibodies against phospholipid antigens (APA) have been demonstrated in adult idiopathic(immune) thrombocytopenic purpura (ITP), but their clinical and pathogenetic significance has remained elusive. Also there are no such studies available in pediatric ITP cases. In this study, the prevalence and clinical significance of APAs were investigated in pediatric patients with ITP.METHODS:
Forty newly diagnosed ITP patients (age 2-13 years) were prospectively studied. They were evaluated for the presence of lupus anticoagulant (LA).RESULTS:
Eleven patients (27.5%) were LA positive at the time of diagnosis. No statistically significant differences were found between the LA-positive and LA-negative groups regarding gender, initial platelet counts, or response to methyl prednisolone therapy. After 6 months of follow up, 5 of the 11 LA-positive cases were still positive for LA. The frequency of LA positivity found in this pediatric age group was similar to that reported in adult patients.CONCLUSION:
In view of the fact that in adult patients with ITP, the persistent presence of APAs is an important risk factor for the development of antiphospholipid syndrome, the same may also hold true for pediatric ITP patients, and thus 'demands long term follow up for these patients.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Feminino
/
Humanos
/
Masculino
/
Criança
/
Pré-Escolar
/
Prevalência
/
Estudos Prospectivos
/
Adolescente
/
Púrpura Trombocitopênica Idiopática
/
Inibidor de Coagulação do Lúpus
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
2004
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS