Gene polymorphisms of IL-6(-174) G/C and IL-1Ra VNTR in asthmatic children.
Indian J Pediatr
;
2008 Oct; 75(10): 1019-23
Artigo
em Inglês
| IMSEAR
| ID: sea-83963
ABSTRACT
OBJECTIVE:
To check for the association of genetic polymorphisms of IL-6-(-174)G/C and IL-1RaVNTR with the susceptibility and severity of asthma in Egyptian children.METHODS:
Subjects included 69 asthmatic children and 98 healthy unrelated controls from the Nile Delta of Egypt. Cases consisted of 20 males and 49 females with an age mean +/- SD is 7.5 +/- 2.1 ranging between 2-13 years. DNA amplification using PCR with sequence-specific primers was done for detection of promotor single nucleotide polymorphism of IL-6 gene as well as intron 2 VNTR of IL-1Ra gene. Frequency of case-genotypes or alleles were compared to controls using Fisher exact test and Odds ratio.RESULTS:
Cases showed significant higher frequency of the genotypes IL-6-174 GG (P<0.05, OR=3.2, 95% CI=1.09-10) that was evident mainly in the uncontrolled asthma subgroup indicative of the possibility of being a severity genotype. All cases as well as case-subgroups showed high significant frequency of IL-1Ra A1A1 (p<0.0001, OR=1.5, 95% CI=1.3-1.8). This may be considered a susceptibility genotype. Cases have also shown significant lower frequency of IL-6(-174) GC and IL-1Ra A1A2 genotypes (P<0.001 and P<0.0001 respectively).CONCLUSION:
IL-6 and IL-1Ra polymorphisms can be considered genetic markers for bronchial asthma susceptibility and/or severity among Egyptian children. This may have a potential impact on family counseling and management.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Polimorfismo Genético
/
Asma
/
Feminino
/
Humanos
/
Masculino
/
Criança
/
Pré-Escolar
/
Reação em Cadeia da Polimerase
/
Adolescente
/
Interleucina-6
País/Região como assunto:
África
Idioma:
Inglês
Revista:
Indian J Pediatr
Ano de publicação:
2008
Tipo de documento:
Artigo
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