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Philadelphia chromosome positive essential thrombocythemia with dilated cardiomyopathy.
Artigo em Inglês | IMSEAR | ID: sea-84964
ABSTRACT
We report here an unusual case of a 30-year old male patient with essential thrombocythemia (ET) and dilated cardiomyopathy, who on further investigation was found to have Philadelphia chromosome positive (Ph+) cells in the bone marrow. The reverse transcriptase-polymerase chain reaction (RT-PCR) test on his peripheral blood leucocytes revealed b2a2 transcript of the bcr-abl fusion gene. Literature shows that the boundary line between Ph+ essential thrombocythemia and chronic myeloid leukemia (CML) is getting blurred day by day. Each one may be a part of the spectrum of a single clonal proliferative disease. Association of dilated cardiomyopathy with ET has not been reported.
Assuntos
Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Cromossomo Filadélfia / Humanos / Masculino / Cardiomiopatia Dilatada / Adulto / Trombocitemia Essencial Idioma: Inglês Ano de publicação: 2005 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: IMSEAR (Sudeste Asiático) Assunto principal: Cromossomo Filadélfia / Humanos / Masculino / Cardiomiopatia Dilatada / Adulto / Trombocitemia Essencial Idioma: Inglês Ano de publicação: 2005 Tipo de documento: Artigo