Prenatal diagnosis in a haemophilia A family by both factor VIII activity and antigen measurements.

ABSTRACT

With the advent of molecular biology techniques prenatal diagnosis in haemophilia A is generally being performed by first trimester chorionic villus sampling followed by the DNA analysis using various polymorphic markers of factor VIII gene. Here we report antenatal diagnosis in a haemophilia A family performed in the second trimester by measuring both factor VIIIC and factor VIIIAg in the fetal blood sample.