Oxidant stress in pre-eclampsia and essential hypertension.
Artigo
em Inglês
| IMSEAR
| ID: sea-86296
ABSTRACT
BACKGROUND:
Endothelial cell dysfunction may play a role in the pathobiology of pre-eclampsia and human essential hypertension. Vasodilators and platelet anti-aggregators such as prostacyclin and nitric oxide are produced by endothelial cells. The half-life of prostacyclin and nitric oxide are reduced by superoxide anion, whereas superoxide dismutase antagonizes its action.OBJECTIVES:
To estimate the plasma concentrations of nitric oxide and lipid peroxides and those of catalase and superoxide dismutase in patients with pre-eclampsia and essential hypertension.METHODS:
Patients of essential hypertension and pre-eclampsia were selected for the study. Nitric oxide and lipid peroxides were estimated in the plasma and anti-oxidants catalase and superoxide dismutase were estimated in the RBC membranes.RESULTS:
The ratio between lipid peroxides and nitric oxide was elevated and the activity of superoxide dismutase reduced in patients with pre-eclampsia and uncontrolled essential hypertension.CONCLUSION:
These results suggest that oxidants and anti-oxidants are altered in human essential hypertension and pre-eclampsia.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Pré-Eclâmpsia
/
Superóxido Dismutase
/
Vitamina E
/
Feminino
/
Humanos
/
Masculino
/
Gravidez
/
Catalase
/
Estresse Oxidativo
/
Adulto
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Ano de publicação:
2002
Tipo de documento:
Artigo
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