Effect of intraesophageal acid instillation on airway reactivity in patients with asthma.
Artigo
em Inglês
| IMSEAR
| ID: sea-86606
ABSTRACT
OBJECTIVE:
To study the change in airway reactivity due to presence of acid in lower esophagus and its reversibility by antacid.METHOD:
In this double blind study 12 subjects with asthma and gastroesophageal reflux received acid (N/10 hydrochloric acid) and antacid (mixture of magnesium trisilicate and aluminum hydroxide) perfusion in lower esophagus via a nasogastric tube. The four combinations were antacid-antacid (control), antacid-acid, acid-antacid and acid-acid. Airway reactivity (Histamine PD20) was recorded after each perfusion.RESULTS:
Histamine PD20 significantly decreased (airway reactivity increased) (p < 0.05) with all three combinations containing acid as compared to control. No significant difference in airway reactivity was observed if the antacid was given before or after the acid.CONCLUSION:
Presence of acid in lower esophagus can increase airway reactivity. This effect lasts longer than the presence of acid in esophagus itself.
Texto completo:
DisponíveL
Índice:
IMSEAR (Sudeste Asiático)
Assunto principal:
Asma
/
Testes de Provocação Brônquica
/
Feminino
/
Humanos
/
Masculino
/
Refluxo Gastroesofágico
/
Volume Expiratório Forçado
/
Método Duplo-Cego
/
Adolescente
/
Hiper-Reatividade Brônquica
Tipo de estudo:
Ensaio Clínico Controlado
Idioma:
Inglês
Ano de publicação:
2000
Tipo de documento:
Artigo
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